A great gaming mouse with side buttons can speed up ability casting, macro use, and everyday shortcuts without forcing your hand off the mouse.
Below, we break down the best options for 2026 so you can match button layout, comfort, sensor performance, and software control to the way you actually play.
Best 10 Gaming Mouse with Side Buttons Picks for 2026
MMO Control Pick
Redragon M908 Wired MMO RGB Gaming Mouse
- 12 programmable side buttons
- Up to 12400 DPI with software adjustment
- 8-piece weight tuning set and 5 profiles
Best For: MMO players who want maximum programmable side-button control
Budget Macro Option
- 6 side buttons and 12 programmable buttons
- 4 DPI levels up to 4000 DPI
- Includes 8 weights and braided cable
Best For: Budget buyers who want thumb buttons and basic customization
High-Command MMO Choice
UtechSmart Venus Pro Wired MMO Gaming Mouse
- 12 side buttons and 19 buttons total
- Up to 16400 DPI with on-mouse adjustment
- 5 profiles with RGB color indicators
Best For: MMO gamers who want extensive remapping and profile control
Precision All-Rounder
Logitech G502 Hero Wired Gaming Mouse
- 11 programmable buttons
- HERO sensor up to 25600 DPI
- Adjustable weights and LIGHTSYNC RGB
Best For: Gamers who want precision tracking and flexible programmable controls
Best for Easy Setup
Redragon M901K 19-Button Macro Mouse
- 12 side buttons plus 19 total programmable buttons
- 12400 DPI with adjustable polling rate
- 8 removable weights and 5 memory profiles
Best For: MMO players who want maximum button density and deep customization
Ergonomic All-Rounder
- 11 programmable buttons with thumb-rest ergonomics
- Focus+ 26K DPI sensor and optical switches
- Hyperscroll tilt wheel for faster navigation
Best For: Players who want comfort, premium tracking, and a versatile button layout
Budget MMO Option
- 15 programmable buttons with 2 + 8 side-button layout
- 5 DPI levels with software-adjustable tuning
- RGB backlighting with multiple modes
Best For: MMO and productivity users who want lots of remappable buttons at a practical price point
Best with Extra Features
Corsair Scimitar RGB Elite Wired MMO MOBA PC Gaming Mouse
- 12 repositionable side buttons
- 17 programmable buttons
- 18,000 DPI optical sensor
Best For: MMO and MOBA players who want dense programmable controls
Wireless Flex Pick
SOLAKAKA SM809 Pro MMO Gaming Mouse
- 9 side buttons with modular panels
- Tri-mode wireless plus USB-C wired
- 24000 DPI sensor with onboard memory
Best For: Gamers who want a flexible wireless MMO mouse with customizable side buttons
Best Simple Pick
Redragon M921 Wired RGB MMO Gaming Mouse
- 12 side buttons and 18 programmable buttons
- Adjustable DPI up to 12400
- Includes weight tuning set
Best For: Gamers who want a value-oriented wired MMO mouse with many programmable controls
MMO Control Pick – Redragon M908 Wired MMO RGB Gaming Mouse
If you want a gaming mouse with side buttons for MMO or macro-heavy play, the Redragon M908 is built around that use case. It gives you 12 programmable side buttons, 18 total programmable buttons, and a DPI range that can be tuned from 500 up to 12400 for different games and tasks.
Best For: MMO players and users who want a highly programmable wired mouse with lots of side-button control.
Pros:
- 12 MMO programmable side buttons and 18 programmable buttons total
- Up to 12400 DPI with 5 preset levels and software adjustment
- Includes 8-piece weight tuning set for a more customized feel
- RGB lighting can be disabled and 5 memory profiles help separate setups
Cons:
- Wired design may not suit users who prefer wireless freedom
- Right-handed shape may not work for everyone
The M908 is a strong fit if your priority is lots of side buttons and deep customization. Its feature set leans heavily toward MMO and multi-command gaming, while the weight tuning and profile system add extra flexibility for everyday use too.
Budget Macro Option – AFUNTA C12 Gaming Mouse
The AFUNTA C12 is a gaming mouse with side buttons aimed at players who want a simple macro-heavy layout without paying for top-tier specs. It includes 6 side buttons, 12 programmable buttons total, and a 4-level DPI switch that reaches 4000 DPI, with double-speed adjustment listed up to 8000 DPI movement speed.
Best For: Budget-minded gamers who want thumb-access side buttons, basic macro control, and adjustable weights.
Pros:
- 6 side buttons plus 12 programmable buttons total
- Built-in 8 weights for a more adjustable feel
- 4 DPI levels with quick switching
- Braided cable and gold-plated USB connector for durability
Cons:
- Maximum DPI is lower than some higher-end MMO mice
- Design and feature set are more basic than premium options
This mouse makes sense if you mainly want practical side-button access and customization rather than advanced sensor specs. It covers the essentials well for gaming and general use, especially if you like a wired mouse with adjustable weight.
High-Command MMO Choice – UtechSmart Venus Pro Wired MMO Gaming Mouse
The UtechSmart Venus Pro is a gaming mouse with side buttons designed for players who want extensive control and quick profile switching. It offers 12 side buttons, 19 buttons total, up to 16400 DPI, and five custom profiles with RGB color indicators to help keep configurations organized.
Best For: MMO players who want a feature-rich wired mouse with lots of remappable buttons and profile-based setup.
Pros:
- 12 side buttons and 19 buttons total for heavy command use
- Up to 16400 DPI with adjustable sensitivity on the mouse
- 5 custom profiles with distinct RGB backlight modes
- Includes 8 internal weights and an ergonomic right-handed shape
Cons:
- Right-handed design limits ambidextrous use
- Wired setup may not suit players who prefer a cable-free mouse
If you need a mouse built around side-button density and profile management, the Venus Pro is one of the most capable options here. Its adjustable weighting, thumb-friendly layout, and high DPI ceiling make it well suited to complex games and repetitive commands.
Precision All-Rounder – Logitech G502 Hero Wired Gaming Mouse
The Logitech G502 Hero is a gaming mouse with side buttons for players who want precise tracking and a balanced control layout. It includes 11 programmable buttons, a high-end HERO sensor up to 25600 DPI, adjustable weights, and a dual-mode scroll wheel for more flexible use.
Best For: Gamers who want a highly accurate wired mouse with programmable side buttons and broad all-around control.
Pros:
- 11 programmable buttons for flexible in-game mapping
- HERO sensor reaches up to 25600 DPI with zero smoothing or filtering
- Adjustable weight system for personalized balance
- LIGHTSYNC RGB and dual-mode hyper-fast scroll wheel
Cons:
- Only 11 total buttons, so it has fewer side controls than MMO-focused mice
- Wired design may not be ideal for users wanting wireless convenience
This is the strongest pick if you want a more versatile gaming mouse rather than a side-button-heavy MMO model. It still offers programmable controls, but its main advantage is sensor quality and a very polished overall feature set.
Best for Easy Setup – Redragon M901K 19-Button Macro Mouse
If you want a gaming mouse with side buttons that can handle MMO hotkeys and everyday use, the Redragon M901K is built around control. It offers 12 remappable side buttons, 19 total programmable buttons, and a high 12400 DPI ceiling, so you can tune sensitivity and binds for different games or work tasks.
Best For: MMO and MOBA players who want lots of remappable side buttons, plus users who like adjustable weight and profiles.
Pros:
- 12 side buttons and 19 programmable buttons for dense keybinding layouts
- Adjustable DPI from 100 to 12400 with 125Hz to 1000Hz polling rate
- Includes 8 removable 2.4g weights for balance tuning
- 5 memory profiles and macro editing for different setups
Cons:
- Wired-only design may not suit those wanting wireless freedom
- Large button count may feel busy if you only need basic controls
This is the most feature-packed option in the group if side-button count matters most. The ergonomic shape and RGB lighting round out a mouse aimed at customization-heavy gaming.
Ergonomic All-Rounder – Razer Basilisk V3
The Razer Basilisk V3 is a gaming mouse with side buttons for players who want an ergonomic shape without giving up customization. It includes 11 programmable buttons, a thumb-rest design, and a Focus+ 26K DPI optical sensor, making it a strong fit for fast-paced play and general PC use.
Best For: Gamers who want an ergonomic wired mouse with easy-to-reach buttons, a scroll wheel with extra control, and premium sensor performance.
Pros:
- 11 programmable buttons for macros and secondary functions
- Ergonomic design with thumb rest for comfortable access
- Hyperscroll tilt wheel with free-spin and tactile modes
- Focus+ 26K DPI sensor and optical switches for responsive tracking
Cons:
- Only 11 buttons, so it has fewer side-control options than MMO-focused mice
- Requires Razer Synapse for full customization
For buyers who care about comfort and accuracy as much as side buttons, this model hits a nice balance. It is less specialized than an MMO mouse, but more refined for mixed gaming and everyday navigation.
Budget MMO Option – Redragon M811 Wired RGB Mouse
If you need a gaming mouse with side buttons for MMO-style hotkeys, the Redragon M811 keeps the focus on utility. It includes 15 programmable buttons, a default 2 + 8 side-button layout, and a DPI range that can be adjusted for different games, making it a practical pick for players who want extra inputs without moving up to a more expensive model.
Best For: MMO players and multitaskers who want a wired mouse with many remappable buttons and solid RGB customization.
Pros:
- 15 programmable buttons with customizable tactical keybinds
- Default 2 + 8 epic MMO side buttons for quick access
- 5 DPI levels with software-adjustable sensitivity up to 12400
- RGB backlighting with multiple modes and software support
Cons:
- Maximum sensor spec in the notes is 6200 DPI in details, so the listed DPI modes may be more complex than the hardware spec suggests
- Wired only, with no wireless option mentioned
This mouse is aimed at buyers who want a lot of side-button utility on a simpler, no-frills platform. It is a strong value-style choice if your priority is remappable controls and MMO convenience.
Best with Extra Features – Corsair Scimitar RGB Elite Wired MMO MOBA PC Gaming Mouse
If you want a gaming mouse with side buttons for MMO or MOBA play, the Corsair Scimitar RGB Elite is built around fast access and heavy macro use. Its 12 repositionable side buttons, 17 programmable inputs, and 18,000 DPI sensor make it a strong fit for players who want dense controls without sacrificing tracking accuracy.
Best For: MMO and MOBA players who want a wired mouse with highly programmable side buttons and a contoured right-handed shape.
Pros:
- 12 side buttons can be repositioned with the patented Key Slider system.
- 17 fully programmable buttons support complex macros and frequent in-game actions.
- 18,000 DPI optical sensor offers fine 1-DPI adjustment steps.
- 50 million click-rated Omron switches and braided cable add durability.
Cons:
- Wired-only connection may not suit users who want wireless freedom.
- Right-hand contoured design will not work well for left-handed players.
This is a practical pick if your priority is side-button access and programmable control over a simple lightweight shell. The shape, sensor, and button count are all aimed at long sessions where quick commands matter.
Wireless Flex Pick – SOLAKAKA SM809 Pro MMO Gaming Mouse
This gaming mouse with side buttons is designed for players who want flexibility across multiple devices. The SOLAKAKA SM809 Pro combines 9 side buttons, 16 programmable inputs, and tri-mode connectivity, so it can move between desktop, laptop, tablet, and wired use without changing your workflow.
Best For: Gamers and multitaskers who want a wireless MMO mouse with modular side-button layout options.
Pros:
- Tri-mode connection supports 2.4GHz wireless, BT 5.0, and USB-C wired.
- 9 side buttons and 16 programmable buttons give you plenty of control.
- 4 magnetic side plates let you change grip and button layout.
- 24000 DPI sensor and onboard memory suit precise, portable use.
Cons:
- Uses an AAA battery setup instead of an internal rechargeable battery.
- Side-button layout may take some setup time because of the modular panels.
Overall, this mouse stands out when you want programmable controls without staying tied to one connection type. The combination of wireless modes, web-based setup, and modular side panels makes it especially adaptable.
Best Simple Pick – Redragon M921 Wired RGB MMO Gaming Mouse
If you need a gaming mouse with side buttons for MMO-style control, the Redragon M921 focuses on value and customization. It includes 12 side buttons, 18 programmable buttons, and five DPI presets, giving you a lot of inputs for macros, keybinds, and fast switching during games or work.
Best For: Players who want a wired MMO mouse with lots of programmable buttons, adjustable weight, and RGB lighting.
Pros:
- 12 side buttons plus 18 total programmable buttons for macro-heavy play.
- Five DPI presets and software-adjustable sensitivity up to 12400 DPI.
- 8-piece weight tuning set helps you tailor the feel of the mouse.
- RGB lighting includes 5 backlit modes and 5 memory profiles.
Cons:
- Wired USB connection only.
- Large button count and aggressive shape may not suit minimal setups.
The M921 is a strong option if you want maximum button access without paying for premium extras. Its programmable layout, weight tuning, and sensor specs make it a versatile pick for both gaming and general use.
How We Picked the Best Gaming Mouse with Side Buttons
We focused on mice that offer practical side-button layouts, reliable sensors, customizable software, and comfortable shapes for long sessions. We also looked for useful differences in weight, grip style, wired connectivity, and macro support so this list covers both MMO-heavy and all-around gaming needs.
Quick Comparison
When comparing a Gaming Mouse with Side Buttons, the biggest differences usually come down to button count, where those buttons sit, and how easy they are to distinguish by feel. MMO-focused models often pack more inputs on the thumb side, while hybrid designs balance extra buttons with simpler ergonomics for FPS or general use.
Key Buying Factors for Gaming Mouse with Side Buttons
Button Count and Layout
More buttons are not always better. If you play MMOs or use many hotkeys, a dense thumb grid can be valuable. For mixed genres, fewer but better-placed buttons often reduce misclicks and feel easier to learn.
Ergonomics and Grip
Look at palm support, thumb rest shape, and overall size. A mouse that feels comfortable for your grip style will usually matter more than raw DPI or RGB lighting.
Sensor Performance
DPI numbers are only part of the story. Consistent tracking, low acceleration, and stable lift-off behavior matter more for accuracy, especially if you switch between fast aiming and precise cursor movement.
Software and Macro Support
Choose a model with straightforward remapping and profile saving if you plan to assign spells, commands, or productivity shortcuts. Good software can make a Gaming Mouse with Side Buttons much more useful day to day.
Wired Vs. Wireless
Wired mice are often the safer value pick for this category because they avoid charging and tend to keep latency simple and consistent. If you prefer clutter-free desks, make sure any wireless alternative still offers the side-button layout you want.
Who Should Buy Which Gaming Mouse with Side Buttons?
MMO and MOBA players should prioritize higher button counts, clear thumb-grid spacing, and strong macro tools. FPS players may be happier with a simpler hybrid mouse that adds a few side buttons without becoming bulky. If you want one mouse for gaming and work, choose a balanced shape with just enough buttons for shortcuts, not an overloaded panel you will rarely use.
In short, the best choice is the one that fits your hand, your genre mix, and the number of commands you actually plan to assign.